5, 10-methylenetetrahydrofolate reductase gene mutation and reproductive outcome: how much do we know? A case series in Indian population
نویسندگان
چکیده
Recurrent pregnancy loss (RPL) defined as of two or more pregnancies is one the reasons why couples visit an ART clinic. 2-5% RPL cases show abnormal parental karyotype. Folic acid essential B vitamin involved in processes fundamental importance for cell division and embryo development. deficiency can have effect on many oocyte development, acquisition endometrial receptivity, implantation also maintenance pregnancy. The 5, 10-methylenetetrahydrofolate reductase (MTHFR) enzyme plays important role folate metabolism. most investigated MTHFR gene mutations are single nucleotide polymorphisms (SNPs) at mRNA positions 677 (rs1801133) 1298 (rs1801131). found less Asian population hence not been studied evaluated much. We presented a case series 3 different mutation variants that were managed our center. Testing after early failures/missed abortions, PGT-A surrogacy being proposed interventions.
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ژورنال
عنوان ژورنال: International journal of reproduction, contraception, obstetrics and gynecology
سال: 2022
ISSN: ['2320-1770', '2320-1789']
DOI: https://doi.org/10.18203/2320-1770.ijrcog20220577